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ADDICTION (ADDICTION IN ANIMALS(monkey) (They Get Hooked Young:, Slaking a…
ADDICTION
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addition basic
Habitual drug use, despite adverse effects on health and
social life and, generally, despite efforts to quit.
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Addiction and physical dependence may occur together or
separately.
• After withdrawal symptoms due to physical dependence have
subsided, addicts may still crave the drug.
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RELAPSE
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The longer the withdrawal period, the more the animals
persisted in bar pressing when the bar
made available again
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THEORIES OF
ADDICTION
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Allostatic Theory
Each time drug experienced
Initial sensitization of reward system
Followed by depression of reward system (withdrawal)
Over repeated cycles, set-point of
reward system shifts downwards
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Theory
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Allostatic theory account for qualitative difference in how
drugs are experienced and importance of abstinence periods
Depressed mood
Importance of stress
Drugs are now sought to feel “normal”
Addiction relies on periods of drug abstinence
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TREATMENTS
Pharmacotherapies
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Chantix (varenicline,smoking)
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Antabuse (disulfuram, alcohol)
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