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Gastroesophageal Reflux Disorder (clinical manifestation (heartburn,…
Gastroesophageal Reflux Disorder
pathophysiology
defective lower oesophageal sphincter function
poor oesophageal
poor local defense mechanisms of oesophageal mucosa
decrease saliva production
delayed gastric emptying
duodenogastric reflux with acid, pepsin, bile
increase intra abdominal pressure
frequent reflux lead to NERD, erosive oesophagitis/ barrett's oesophagus
complication: oesophageal carcinoma
clinical manifestation
heartburn
dysphagia
bloating
epigastric pain
regurgitation
burping
early satiety
food repeating
investigation
AXR
ambulatory pH monitoring
endoscopy
esophageal manometry
interventions
lifestyle modification
medication
antacids
H2RAs
PPI