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Peptic Ulcer - ulceration in the mucosa of the lower oesophagus, stomach,…
Peptic Ulcer - ulceration in the mucosa of the lower oesophagus, stomach, duodenum
cause
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multifactorial: inflammation, acid secretion abnormality, mucosal barrier efffect
clinical manifestation
epigastric pain
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Indication: sudden, intense midepigastricnpain radiating to the right shoulders
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haemorrhage
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anaemia, dizziness, syncope
perforation
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s/s if acute symptoms of acute abdomen with sudden onset of severe, localised epigastric pain
peritonitis develops when pain become generalised right abdomen with decrease bowel sounds and shock
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medication
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H2RA
famotidine - pepcidine
therapeutic actions: inhibits stimulation of gastric parietal cells at H2 receptor sites, decrease gastric acid secretion, promote healing of acid-sensitive ulcer
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side effect:
- CNS: confusion;
- GI: nausea, diarrhea, abdominal pain
PPI
pantoprazole (pantoloc)
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indication: severe erosive GERD, not responsive to H2RA
side effect: overproduction of gastrin
CNS: headache, dizziness, fatigue
GI: nausea, diarrhea, abdominal pain
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antiemetics - treat underlying cause of nausea, vomiting
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