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Male Contraception (Testes Function (HPG-Axis regulates spermatogenesis +…

- - - - 1 year; tallied number of pregnancies; 70% had 0sperm; PR = 1.4 in 100
    - - <3million/l; 90% men suppression of spermatogenesis; 8 in 100 PR; effective as condoms; identified relationship between sperm count and pregnancy risk
  - - - 8-week injections; 7 countries involved; 2008-2011; 91% high sperm suppression; PR 1.5 in 100; discontinued in 2014 because of severe side effects (true method failure)
- - - - sperm count fell in dose-dependent manner
      - Martin et al. 2000
      - some severe oligospermic; others complete azoospermia
    - - P
      - Nexplanon implant
      - 28 men; either 1 or 2 implants
      - removed after 24 weeks; oligospermia achieved with 50% males with 2 implants (<1million.ml); less in 1 implants
      - Anderson et al. 2012
  - - - not reduced by 5a-reductase