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Trials (DCCT (arms (conventional therapy A1C 9%, intensive therapy A1C…
Trials
DCCT
when
1982-1993
who
T1DM
arms
conventional therapy A1C 9%
intensive therapy A1C 7%
effects on complications
reduction of complications
retinopathy
76% reduction
nephropathy
34 % less microalbumiuria
neuropathy
69% less
heart disease
reduction in risk fators
UKPDS
when
1977-1997
who
T2DM
arms
conventional therrapy
A1C target 7.9%
intensive theraphy
A1C 7.5%
what
complications
effect of intensive therapy
retinopathy
21% risk reduction
nephropathy
34% risk reduction (microalbuminurea)
heart disease
16% risk reduction (MI)
ACCORD
ADVANCE