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intro 2 anemia (symptom (malaise, sob, palpitation), CBC (hematocrit (HCT…

- - - - % of RBC
        
        polycythemia vera
  - - - Hb/HCT
        
        spherocytes
  - - - different sizes
        
        iron-deficiency anemia
- - - - microcytic
        
        smaller than lymphocyte's nucleus
  - - - hypochromic
        
        central pallor > 1/3
- - - - iron
        
        iron-deficiency anemia
      - protoporphyrin
        
        sideroblastic anemia
    - - thalassemia
        
        imbalance of globin chains
      - variant Hb
        
        sickle cell disease
        
        HbS: α2β2S
        
        β globin (x glutamic acid v valine)
        
        sickle cell crisis
        
        low o2 tension, HbS crystals, polymerize, sickle
        
        hemolysis
        
        obstruct, infarct: pain
- - - - bone marrow aspiration
        
        hypercellular
      - blood film
        
        reticulocytosis/polychromasia
    - - uncon bilirubin, LDH
        
        fluctuating jaundice pigment stones
        
        cholecystectomy
      - extravascular hemolysis
        
        normal
        
        (marrow, liver, spleen) RE system
        
        moderate splenomegaly
        
        splenectomy (overwhelming post-splenectomy infection OPSI)
      - intravascular hemolysis
        
        no use
        
        hemoglobin-haptoglobin complex
        
        hemoglobinuria, hemosiderinuria: iron-deficiency anemia (G6PD, PNH, cold AIHA, red cell gragmentation syndromes)