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dyslipidemia (Statin: 1st line (benefits (lower LDL, at high dose, lowers…
dyslipidemia
Statin: 1st line
benefits
lower LDL
at high dose, lowers TG
at high dose raise HDL
lowers TC
drugs
Atorvastatin
Lipitor
10 mg - 40 mg pills
Parke-Davis
Rosuvastatin
Crestor
Simvastatin
Zocor
5 mg - 80 mg pills
Merck Frosst
Pravastatin
Pravachol
side effects
hepatitis
jaundice
muscle pain or cramps
caution
check AST & ALT
check CK
pathophysiology
inhibits liver enzyme from making cholesterol
Nicotinic acids
benefits
raise HDL
lowers TG
lowers LDL
drugsniacin
side effects
bad on bs
Bile acid sequestrants
benefits
lowers LDL
side effects
GI - worse with high dose
elevates TG
Fibrates
benefits
lower TG
variable feffect on LDL
variable effect on HDL
drugs
fenofibrate
Lipidil
Choles. absorption inhibitor
drug
Ezetimibe
Ezetrol
benefits
lowers LDL