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TZD (side effects (weight gain, risk of edema, risk of CHF, risk of…
TZD
side effects
weight gain
risk of edema
risk of CHF
risk of fractures
incr. LDL
incr. TC:HDL
contraindication
CHF
pregnancy/breastfeeding
liver problems
DKA
cautious at eGFR below 30
danger for fluid retention & CHF
benefices
decr. A1C by 0.8%
NO hypoglycemia
decr. fbs by 2.8 points
incr. HDL
decr TG
timing
onset
peak
2-4 hrs
duration
full effectiveness
2-3 months
start seeing effect
2-3 wks
drugs
Pioglitazone
Actos
start: 15 mg od
max 45 mg
Rosiglitazone
Avandia
start: 4 mg od
max: 8 mg
pathophysiology
enhance insulin sensitivity
in liver
in peripheral tissues