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BONES FORM + FUNCTION (Functions: (Mechanical (Locomotion), Metabolic…
BONES FORM + FUNCTION
Functions:
Mechanical
Locomotion
Metabolic
Maintenance of blood calcium
Hematopoietic
Bone marrow
Blood vessels
Volkmann's canals
Perforating
Central canal
Functions:
Transport nutrients
Stem cell route
Molecular Composition
Organic
Proteins
Collagen
Type 1
90% of protein
Proteoglycans
Noncollagenous proteins
Ostieoid
Inorganic
Hydroxyapatite crystals
Cells
Osteoblasts
FORMATION
Secrete matrix
Derived from mesenchyme
Becomes osteocyte
Osteoclasts
RESORPTION
Derived from Hematopoietic cell
Osteocytes
Mediate effect of mechanical loading
Regulate phosphate homeostasis
Derived from mesenchyme
Express high levels of Rank Ligand
Classification:
Histological
Woven
Immature
Random orientation
Rapid formation
Rapid turnover
Lamellar
Mature
Regular orientation
Slow formation
Slow turnover
Anatomical
Cortical (compact)
Strong
Unit
Osteons
Radiating caniculi
For communication
Osteocytes in Lacunae
Haversian canal
Periosteum
Outer layer of all bones
Trabecular (cancellous)
Not very strong
Metabolically active
Large surface area
Found with bone marrow
Unit
Trabecule
Targets:
Minimum weight
Maximum mechanical strength
Mineralisation Process
Provides resistance to compression + rigidity
Depends on hormonally active vitamin D
Deficiency
Osteomalacia
Rickets
LO's: