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GLP-1 receptor agonist (incretin) - tide (pathophysiology (suppress…
GLP-1 receptor agonist
(incretin)
- tide
side effects
GI side effects (transient)
pathophysiology
stimulate insulin secretion
suppress glucagon secretion
glucose-dependent
slow gastric emptying
increases satiety
GLP-1 mimetic
greater effect to oral sugar than IV
improves pc bs
drugs
Exenatide
Byetta
start 5 ug
bid
max: 20 ug
Liraglutide
Victoza
Novo Nordisk
Saxanda
wt loss
start: 0.6 mg
od
max: 1.8 mg
contraindications
hx of pancreatitis
hx of medullary thyroid cancer
Stop Liraglutide with eGFR of 50
Cautious with Exenatide at eGFR of 50
stop Exenatide at eGFR of 30
Benefits
decreases A1C by 1.0%
weight loss
no hypoglycemia
improves pc bs
