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Proteinase Inhibitors (Darunavir (DDI w/ PRAVASTATIN!, BID if resistance …
Proteinase Inhibitors
Darunavir
DDI w/ PRAVASTATIN!
BID if resistance
to keep levels up
(qd if not)
very potent & very few SE
caution in Sulfa allergy
but x-reactivity is low
Clinical Pearls
All Need Boosters!
Cyp 3A4 substrate
(and some inhibitors)
"avir"
Side Effects
Metabolic
Hyperglycemia
and
Hyperlipidemia
Lots of DDI!
Boosters
Ritonovir
If give PI BID then give
booster BID @ same time
Has HIV activity (is PI)
Always 100mg
(max dose 200mg/day)
Potent 3A4 inhib
Cobistat
also good
No HIV activity
Lopinavir
Diarrhea is a serious SE
Comes in combo w/ Ritonavir
(Kaletra)
Atazanavir
*
Rqrs acidic environment
(avoid w/ PPIs while using)
SE
Indirect Hyperbilirubinemia
benign
Nephrolithiasis
(kidney & gall stones)
MoA
Vert last step after integration
packaging & snipping is needed
Protease is needed for packaging
Indinavir
Must have lots of fluid
every time you take
(1L/dose)