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part 2 (phoro-oncogenes (Classes (Protein kinases, add phosphate groups to…
part 2
phoro-oncogenes
def: genes that produce normal gene products and stimulate normal cell development
are involved in positive control of cell growth and division
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Classes
Protein kinases, add phosphate groups to target proteins,
important in signal transduction pathways
Membrane-associated G proteins, are able to hydrolyze GTP
to GDP in signaling pathways.
Growth factors, regulatory genes involved in the control of cell
multiplication.
oncoggenes
Arise from mutant protooncogenes and are more active than normal, or active at inappropriate times, and stimulate unregulated cell proliferation
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Ras G-protien
steps
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Ras protein is a G protein relays a growth signal from a growth factor receptor to a cascade of protein kinases
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K-ras oncogene increases level of transcription factors 4-20 fold in colon carcinoma and 30-60 fold in adrenocortical carcinoma
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