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cancer genetics (DNA repair gene (type (Nucleotide Excision Repair,  Base…

- - - - BRCA1 important for homologous
        recombination, cellular repair of DNA
        damage, and transcription of mRNA
      - BRCA2 plays a role in timing of
        mitosis in the cell cycle
- - - - second mutation occurs in one of the retinal cells at an early age, leading to disease
      - have already received one mutation from one of their parents
      - develop multiple tumors involving both eyes
    - - rare events
      - Occurs much later in life
      - must have two mutations
      - tumor develops in one eye only
  - - - Activates genes that arrest cell division and repress other
        genes that are required for cell division
      - Activates genes that promotes apoptosis
      - Activates genes that promote DNA repair