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Parkinson (Pathogenesis: (genetic <50y/o, oxidization rxn w/ generation…
Parkinson
Pathogenesis:
genetic <50y/o
oxidization rxn w/ generation free radicals
idiopathic
Dec. lvl of dopamine in basal ganglia
TICS
Repetitive sniffing
shoulder shrugging
Sudden coordinated abnormal mvmts
face & head mvmt
Chorea
Impaired voluntary activity
ballismus
unpredictable involuntary jerks
Nonmotor symptoms:
20-90% major depressive episode
Motor symptoms:
Positive symptoms
Tremor
Chorea,
Athetosis
Ballismus
Negative symptoms
Loss of postural reflexes
Akinesia
Bradykinesia