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macrolide (Azithromycin (Gram-Negative Aerobes, NOT have activity against…
macrolide
Azithromycin
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More effective on Gram-negative bacteria, H.influenzae, Legionella.
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Clarithromycin
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strongest activity on Gram-positive bacteria,
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Erythromycin
problems : Acid labile, Narrow, Poor GI, short 1\2 life
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- Anaerobes – Upper airway anaerobes
- Atypical Bacteria – All have excellent activity • Legionella pneumophila - DOC
bacteriostatic , at high dose cidal
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Erythromycin and Clarithromycin ONLY– are inhibitors of cytochrome P450 ; may increase concentrations of other drugs
• ENTinfections,Tonsillitis,URTI
• Mycoplasmapneumonieinfections
• Chlamydialinfections(anymacrolides)
• Diphtheria(erythromycin)
• Whooping cough, is a highly contagious respiratory disease. It is caused by the bacterium Bordetella pertussis.(erythromycin)
• Strep/Staph Infections; alternatives in patients allergic to Penicillin
• Prophylaxis against endocarditis in dental procedures
• Campylobacter/ Helicobacter Infections: clarithro
• Tetanus: in patients allergic to Penicillin
• Mycobacterial Infections: Clathri / Azithro Ist choice