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Ribonucleotide Reductase (structure (R1 (2 Regulatory sites (Substrate…
Ribonucleotide Reductase
Definition
enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides
structure
R2
homodimer makes free radical ( tyrosyl radical
Reduction Ribonucleotide Reductase
R1
1 active site
2 Regulatory sites
Substrate speciificity
control levels of each dNTP
Primary regulation site
control overall activity
Function
conversion of ribonucleotides to 2′-deoxyribonucleotides
precursors needed for both synthesis and repair of DNA.
Catalytic Reduction Mechanism
Regualtion
activity sites bind
ATP
dATP
Inhibitors
FdUMP
an irreversible inhibitor of thymidylate
syntahse
