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Bite from Infected Mosquito (portal of entry in the skin (incubation…
Bite from Infected Mosquito
Endemnicity of vector
Stagnant water in area suitable for vector breeding
hobbies or activities outdoors predisposing contact with vector
portal of entry in the skin
incubation period
Viremia
Entry to other organs
Afebrile Phase
Liver
necrosis of hepatocytes
hepatomegaly
Liver cirrhosis
Abdominal pain
Release of toxins to blood
Increased coagulation
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Bone Marrow
Thrombocytopenia
Bleeding
DHF
#
suppressed hemopoiesis
#
Spleen
Splenomegaly
Recovery of Symptoms
Recovery Phase
Endothelial damage
Plasma leakage
3rd space loss
narrow pulse pressure
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hypotension
Shock
Ascites
Pleural effusion
Stimulation of Immune response
Fever
Febrile phase
Diaphoresis
headache
High grade fever
Body malaise
Asymptomatic
Redness and pruritus in area of bite