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CEPHALOSPORIN (II Generation (Cefmetazole, and cefotetan active against…
CEPHALOSPORIN
II Generation
Cefmetazole, and cefotetan active against anaerobes.
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Cefaclor,
Cefuroxime, Cefonicid,
Cefoxitin
Ceforanide Cefprozil
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Greater spectrum of activity against Gram-negative organisms such as H. influenze, Enterobacter aerogenes and Neisseria sp.
Ineffective against, Enterococcus and Actinobacter species and anaerobes
III Generation
have a broad spectrum of activity and expanded gram-negative coverage, and some are able to cross the BBB.
Most effective of the cephalosporins against antibiotic- resistant gram-negative aerobes, effective against Proteus vulgaris, Enterobacter species, Citrobacter species, Haemophilus species, Neisseria species
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Used to treat bone and joint infections, pneumonia, endocarditis, rhinosinusitis and cystitis.
I Generation:
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Active against gram + cocci, pneumococci, streptococci and staphylococci.
Oral drugs : UTI, cellulitis or soft tissue abscess
Cefazolin penetrates the most tissues. They are used to treat bone and joint infections especially in the treatment of open fractures, lymphadenitis, abscesses, pharyngitis, etc.
1- Drug of choice for surgical prophylaxis.
2- Streptococcal or staphylococcal infections who have history of penicillin allergy. 3-Does not penetrate the CNS
IV Generation
• Many can cross blood brain barrier and are effective in meningitis.
• Highly active against Haemophilus and Neisseria.
High activity against Enterobacteriaceae, moderate activity against Pseudomonas aeruginosa and enhanced activity against staphylococci
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