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ANTIBODY STRUCTURE + FUNCTION (Binds to protein (Avidity increases…
ANTIBODY STRUCTURE + FUNCTION
LO's:
Structure of antibodies, recognise classes and subclasses.
Describe the function of various classes
How class relates to biological function
Structure:
Soluble proteins
Chains:
LIGHT
Types:
Kappa
Lamda
HEAVEY
Types/Class:
IgE
Mediates allergic hypersensitivity
Defends against parasites
IgM
Surface of B cells
IgD
Surface of B cells
IgA
In external secretions - prevents bacterial pathogens
Dimer for stability
IgG
Surface of B cells
NEUTRALIZES
Viruses
Toxins
Regions:
VARIABLE
Mutations more common
CONSTANT
Decides biological activity
Opsinisation
Activate complement
FcR mediated activity
Location:
Milk
Blood
Secretory fluids
Mucus
PRODUCED BY B CELLS
Function:
Specificity
Gene segment recombination diversity
Biological activity
Activate complement
Binds to protein
Hydrogen bonds
Affinity increases
Avidity increases
Measure of strength of attachment at multiple sites
Van der Waal bonds