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CELL CYCLE 2 (G2 Phase (Function: (Repair DNA damage, Repression of gene…
CELL CYCLE 2
G2 Phase
Prep for mitosis
Sister chromatids linked by centromere
Cancer cells bypass
Function:
Repair DNA damage
Repression of gene activity
Regulated:
Cyclin B
LO's
Describe G2 phase + stages of mitosis
Understand roles of cyclin
Checkpoints
Role of actin and myosin in Cytokinesis
Microtubules
Comp:
Alpha tubulin
Beta tubulin
Have a + and - end
Component of cytoskeleton
Molecular motors
Use ATP
Examples:
Dynein
Moves to - end
Kinesin
Moves to + end
Move along MT
Align Chromosomes during mitosis
Mitosis
Stages;
Prophase
Visible Chromosomes
CyclinB-CDK phosphorylates
Activates condensin
Prometaphase
Nuclear membrane disappears
Chromosomes captured by microtubules
CyclinB-CDK phosphorylates (breaks down)
Lamin
Component of membrane
Metaphase
Chromosomes line up
CHECKPOINT!
Assures correct line up
CyclinB-CDK phosphorylates
Separase to inactivate
Anaphase
Sister chromatids pulled apart
Kinesins depolymerize microtubules
Seperase activated
CyclinB + securin degraded
Telophase
Chromosomes decondense
Nuclear envelope reforms
Lamin activated
Spindles degrade
RB dephosphorylation
cell cycle inhibited
Cytokinesis
Contractile ring
Actin + myosin