Please enable JavaScript.

Coggle requires JavaScript to display documents.

CELL CYCLE 1 (Why cells divide? (Meet cell needs (Produce enough RNA…

- - - - Important for protein function
- - - - Progress:
        
        Checkpoint
        
        Check for DNA damage
        
        Ensure repair
        
        Or apoptosis
        
        Induce p53 stabilization
        
        Must inactivate RB inhibitor
        
        E2F
        
        Transcription factor
        
        Needed for G1 to start mitosis
      - Growth
    - - Synthesis
      - 10-12 hours
      - Progress:
        
        Accurately Replicate DNA
        
        Package
        
        Form Chromosome
        
        Enzymes:
        
        DNA Helicase
        
        Unzips
        
        Breaks hydrogen bonds
        
        DNA Polymerase
        
        Adds nucleotides
        
        Semi-consrvative
        
        ORI's
        
        Specific region
        
        Enzymes bind
        
        Contains many T's + A's
        
        Weaker bonds
        
        Regulated by CDK complexes
        
        Phosphorylation is needed
    - - Mitosis prep
  - - - Resting
    - - Enter phase when mature
        
        Osteocytes
        
        Cardiac muscle
        
        Nerve cells
      - Smaller, less metabolically active
    - - Mitogen stimuli
- - - - G1
    - - G1/S
    - - S
    - - Mitosis
- - - - Checks DNA integrity