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endocrine 3 thyroid ((cardiovascular, respiratory), (metabolic rate,…
endocrine 3 thyroid
cardiovascular
respiratory
metabolic rate
metabolic substrate
CNS
bone
(β receptor) SNS
(synergize with catecholamines) SNS
free T3
TSH
low
high free T3: T3 toxicosis
free T4
normal/low
normal free T3: subclinical primary hyperthyroidism
hypothyroidism
primary
free T4
low
TSH
high
secondary
TSH
low
free T4
low
hyperthyroidism
primary
free T4
high
TSH
low
secondary
TSH
high
free T4
high
primary
hyperthyroidism
Graves
TSH receptor antibodies
hypothyroidism
Hashimoto
anti-thyroglobulin, anti-thyroid peroxidase
central hypothyroidism
TRH stimulation test
thyroid hormone synthesis
follicular epithelial cell
T3, T4 to blood, MIT, DIT's iodine to recycle
endocytosis
TPO thyroid peroxidase
coupling of 2 iodotyrosines = iodothyronine (T3, T4)
TPO thyroid peroxidase
iodination of tyrosine = iodothyrosine (MIT, DIT)
TPO thyroid peroxidase
oxidation of iodine
Na/I symporter
autoregulation (Jod-Basedow effect)
Wolff-Chiakoff effect
pharmalogical (iodine escape)