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imm 2 complement (pathway (alternative (innate immunity (tickover/properdi…
imm 2 complement
pathway
alternative
innate immunity
tickover/properdin/protease
lectin
innate immunity
lectin is the receptor for mannose on bacteria
classical
adaptive immunity
antigen-antibody
complement
initiation
lectin, classical
C4b2a
alternative
C3bBb
C3 convertase
opsonization, inflammation
C5 convertase
membrane attack complex: cell/immune complex
PNH
aetiology
X chromosome somatic mutation
2 venous thrombosis 3 bonem marrow failure
no CD55, CD59
1 intravascular hemolysis
complement
no GPI anchor
diagnosis
fow cytometry
no GPI anchor
treatment
complement
monoclonal antibody: eculizumab
thrombosis
warfarin
bone marrow
hematopoietic stem cell transplantation
immune complex
SLE
vasculitis
glomerulonephritis
complement
liver
glycoproteins