Please enable JavaScript.
Coggle requires JavaScript to display documents.
THE MHC: IMMUNOGENETICS (Features: (Polygenic (Inheritance: (6 molecules…
THE MHC: IMMUNOGENETICS
Recognising protein
B cells recognize native proteins
T cells recognize degraded proteins bound by MHC
Features:
Polygenic
Inheritance:
6 molecules
3 of each type from each parent
Co-dominant
Polymorphic
To recognise wide variety of antigen protein
Glycoproteins
Function:
Present antigen peptides to T cells
Class 1
Take up peptides from viruses and bacteria that replicate within the cell
Generally nucleated cells
Class 2
Take up peptides from pathogens taken up by phagocytosis and endocytotic vesicles
Comp:
Peptide binding groove
Induced fit
Alpha sub-unit
Beta sub-unit
Pathology
Poor genetic diversity
Increased risk of infection
Cheetah's
Devil disease
Transplant rejection is due to MHC incompatibility
Certain MHC haplotypes associated with disease
Autoimmunity/ allergy/ diabetes
MHC's are expressed on all cells of the body