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Penicillin (Natural Penicillin: (Penicillin G, Penicillin V, Narrow…
Penicillin
Natural Penicillin:
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Narrow spectrum, β-lactamase sensitive
Streptococcal infection ( Pharyngitis, Otitis media,
Rheumatic fever),
Pneumococcal infection :
Meningococcal infection : like meningitis, Gonorrhea
Gram + (ve) bacilli
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Extended spectrum
:no_entry:Beta lactamase inhibitors : Clavulanic acid, sulbactam, Tazobactam
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Anti staphylococcal
Nafcillin, Methicillin, Cloxacillin
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Narrow spectrum, β-lactamase resistant
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:no_entry:most are eliminated through active tubular secretion. Nafcillin and oxacillin eliminated largely in bile