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opioid 2 (Pentazocine (agonist on κ receptors in the spinal cord, and is a…
opioid 2
Pentazocine
agonist on κ receptors in the spinal cord, and is a weak antagonist at μ and δ receptors.
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respiratory depression, decreases GIT activity, increase blood pressure and can cause hallucinations, nightmares, dysphoria, tachycardia, and dizziness
Tramadol and Tapentadol
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tapentadol does not produce active metabolites,
centrally acting analgesic that binds to the μ-opioid receptor and they are weakly inhibitors of norepinephrine and serotonin reuptake
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Codeine
the antitussive effect of codeine is due to codeine itself, at doses that do not cause analgesia.
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Opioid Antagonists
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Naloxone is used to reverse the respiratory depression of opioid overdose within 30 seconds of an IV injection
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