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Anti-fungal Drugs (Classification/types of fungal infections (Subcutaneous…

- - - - Terbinafine
        
        Inhibit ergosterol biosynthesis @ level of squalene epoxidase
    - - Tolnaftate
        
        Inhibit ergosterol biosynthesis @ level of squalene epoxidase
    - - Fluconazole
        
        Itraconazole
        
        Ketoconazole
        
        Inhibit ergosterol biosynthesis @ the level of C14-demethylase
    - - Flucytosine
        
        Inhibit DNA & RNA synthesis via conversion of 5-fluorocytosine to 5-fluoricil
    - - Griseofulvin
        
        Inhibits mitosis (sliding of microtubules) in fungi
    - - Flurbiprofen
        
        Ibuprofen
        
        Direct damage to fungal cytoplasmic membrane
    - - Amphotericin B
        
        Nystatin
        
        Interacts w/ sterols in cell membranes forming channels that leak cellular contents
  - - - Chemical type:
        1) Azoles
        
        Mode of action:
        Inhibit ergosterol synthesis
        
        Drug:
        
        Clotrimazole
        
        Ketoconazole
        -
        
        Fluconazole
        -
        
        Itraconazole
        
        Voriconazole
        
        Spectrum:
        
        Medium, local
        
        broad, systemic
        -
        
        broader, systemic
        -
        
        Broader, systemic
        
        broadest, systemic
      - Chemical type:
        2) Allylamines
        
        Mode of action:
        Inhibit ergosterol synthesis
        
        Drug:
        
        Terbinafine
        
        Spectrum:
        
        Skin & nail infection
    - - Chemical type:
        Polyenes
        
        Mode of action: Membrane leakage via ergosterol binding
        
        Drug:
        
        Amphoteracin B
        
        Nystatin
        
        Spectrum:
        
        Very wide
        
        Local candidiasis
  - - - Azoles
    - - 5-Flucytosine
    - - Terbinafine
        
        Naftifine
        
        Butenafine
    - - Griseofulvin
    - - Amphotercin B
        
        Nystatin
    - - Ciclopirox
        
        Tolnaftate
        
        Haloprogin
        
        Undecyclenic acid
        
        Topical azoles
    - - Caspofungin