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Anti Anginals (CALCIUM BLOCKERS (CLINICAL USE (NIFEDIPINE (Does not…

- - - - Suffix: -pine
        
        Greater ration of vascular smooth muscle effects
        
        Cannot slow down heart rate
    - - Does not have common suffix
        
        Slows heart rate but no dilatation of arteries
  - - - Does not decrease AV conduction
    - - CAUTION for heart failure
        May worsen condition
    - - Not contraindicated for heart failure
- - - - Increased cardiac contractility
      - Tachycardia
  - - - Less wall tension, less demand
  - - - Isosorbide dinitrate
      - Dose: 2.5-5mg
      - Duration: 6-10h
    - - Isosorbide mononitrate
  - - - Most frequently used
        
        Immediate treatment 1-3m
        
        Not suitable for maintenance therapy
        
        Short duration of action 20-30m
    - - Rapid onset but quickly reversed
        
        For severe recurrent angina
        
        For heart attack or unstable angina
    - - For those with problems of tolerance
        
        Buccal, oral, or transdermal
    - - Similar to those of nitrates
    - - Blood vessels do not constrict for 24 hours
        
        Effects do not persist for more than 6-8h