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THE LIVER (STRUCTURE (HEPATIC CELLS (hexagonal LOBULE (Contains many cells…

- - - - Contains many cells w central vein (to HT)
        
        Kuppfer cells - macrophages
      - sinusoids
        
        PORTAL TRIAD
        
        Portal vein
        
        Bile Duct
        
        Hepatic Artery
- - - - Storage of Nutrients
        
        FATS
        
        Glycgen
        
        Lipoproteins
        
        Triglycerides
        
        CHO
        
        Glycogen
        
        Lipoproteins
        
        Triglycerides
        
        PROTEINS
        
        Made into ALBUMIN & sent to blood
    - - Cytochrome p450 enzymes Dont bind specifically. Multiple substrates.
        
        can decrease DRUG efficacy
- - - - marker hep inflammatin
      - low specificity for LIV
      - seen in peri portal hepatocytes
      - more specific for muscle
      - Both ALT & AST go up in recent LIV injury
    - - marker hep inflammation
        
        high specificity
        
        goes up in all forms acute LIV injury
    - - Factors related to VIt K - 2, 7,9,10
      - reliable for acute & chronic d.
      - INR (PT about 10 x INR)
    - - made in liver
      - reliable for chronic hepatocellular injury
      - 20 day 1/2 life