Hypo [reduced pulse rate + cardiac output, hypoventilation, CNS depression, hyporeflexia, decreased renal blood flow, loss of shivering; Atrial fibrillation, bradycardia and other arrhythmias] Hyper [core body temp > 40ºC ; sinus tachycardia, tachypnea, widened pulse pressure, hypotension ; flushing (cutaneous vasodilation), tachypnea, crackles due to noncardiogenic pulmonary edema, excessive bleeding ; altered mental state, slurred speech, irritability, inappropriate behavior, agitation, ataxia, delirium]