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Rotavirus (About (Factors Affecting Severity (In cattle reduced intake of…

- - - - Lots of episodes
      - Very few deaths
- - - - Outer layer then removed on entry
    - - Host restriction factor
  - - - Allows for reassortment
      - Means get LOTS of varitation
      - At all segments
  - - - Blunts IFN response
    - - Pathogenicity determinant
    - - Inhibit mRNA cell translation
  - - - Most human cases group A
    - - VP7
      - Glycosylated protein
    - - VP4
      - Protease sensitive protein
- - - - Also by released NSP4
    - - Get water loss in lumen
    - - Water loss as drawn away by a gradient
- - - - IFN7, IFN3, NFkB
- - - - Multivalent
      - 1998-1999
      - Caused what was thought to be excessive inssuseption
      - Therefore withdrawn
      - Was very effective
    - - Merk (company)
      - 2006
      - Didn't know what caused inssusep
      - Reassorted virus with VP4+7
      - G1,2,3,4 serotype protective
      - Very effective
    - - Monovalent G1 though protective against G1,3,4,9
      - Oral
      - UK
    - - Probs socioeconomic