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Crystal-Induced arthritis (Gout (Factors (Heavy alcohol consumption,…
Crystal-Induced arthritis
Gout
leads0>chronic tophaceous arthritis; form tophi
acute arthritis by crystalization of MOSODIUM URATE
TYpes
Primary
90% cases, unkwown cause
small HGPRT def. affected
Secondary
Factors
Heavy alcohol consumption
abnormali HGPRT, multifactorial inheritance
Age 20-30 yrs of hyperuricemia
Morpho
Acute arthritis-dense Neutro infil permeates synovium & Syn Fluid
Chronic tophaceous arthritis
tophi in various sites
Gouty nephropathy
4 Clin stage of gout
Asymtomatic hyperurcemia
acute arthritis
asymptomatic interctitical gout
Calcium pyrophostphate crystal depo DIs
Pseudo gout or Chondrocalcinosis
cause germline mutation in pyrophophate transport chnnel
basiscrystal formation unkwnos