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3D PRINTING (bioinks must be (mechanical properties, degradation kinetics,…
3D PRINTING
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3d printing technologies
Particle fusion
(most widespread for TE.
hard tissue applications.
resolution affected by particle size)
SLS
(laser beam to polymers above Tg.
can use ceramics or metallic powders.
laser scans a layer and then a new
layer of powder is added.
slow and expensive)
PB
(using liquid binding solution within each layer
Light assisted
()
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LIFT :<3:
(transparent layer+absorption layer+deposition layer
CAN USE CELLS AND DEPOSIT THEM
WHEREVER WWE WANT)
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Inkjet :<3:
(Can use CELLS
but might affect
viability.
RESOLUTION DEPENDS ON
COALESCENCE AND
INTERACTION WITH SUBSTRATE)
CIJ
(fluid from reservoir to nozzles
cont stream at high f thanks to
piezoelectric crystal.
Electrodes + deflection plate for drop selection)
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Hydrogels
Characteristics
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Self assembly, shear thinning
types
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ideal cell ink
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if cells are part of the formulation,
viscosity must allow mixing and
homogeneous distribution
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Approaches
DWBP 2
Decellularized ECM from adipose, cartilage and cardiac. PCL + hydrogel
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DWBP4
shear thinning physical hydrogels. fast recovery, UV light
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Polymer biomat inks
PCL
(low cost, biodegradable, good mech prop, low Tm fro FDM
good for SLS
PEEK
(Semicrystalline. good for cranial implants
high tm only with SLS
inert, biocompt, radiolucency, low heat conduct,, good strength.
very inert, no osteointegrative)
PLA
(FDM
low cost, nontoxic, biocompatible, easy processability
brittle and low compressible strength
no heating plate and no smell)
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