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BONES (Bone Matrix (Matrix synth: (Woven bone (prod. rapidly,(fetal devt,…
BONES
Bone Matrix
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Hydroxyapatite 99% calcium, 85% phosphorus
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Matrix synth:
Woven bone
prod. rapidly,(fetal devt, fract repair) haphazard coolagen -> Dec. structural integrity
Lamellar bone
slowly produced, parallel collagen fibers
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Cells
Osteocytes
Osteocytes-fx bone calcium & phosphate homeostasis, [mechanotransduction] derive=osteoblasts
Osteoclasts
2 wks, fx=resorption;MCSF, IL-I, TNF
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Osteoblasts
bone matrix synth; mineralization,derive from osteoprogenitor cells--pluripotent mesenchymal stem cells
synt, transport, assemble matrix, regulate mineralization
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