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Blood pressure (Intrinsic Direvctly regulates GFR despite moderate…
Blood pressure
Intrinsic
Direvctly regulates GFR despite moderate changes in BP 80-180mm Hg
Decrease blood pressure in afferent arterioles
Decrease GFR
Stretch of smooth muscle in walls of afferent arterioles
Vasodilation of afferent arterioles
Increase GFR
MYOGENIC MECHANISM AUTOREGULATION
Low GFR
Decrease filtrate flow
Decrease NaCl in Ascending limb nephron loop
Macula densa cells on juxtaglomerular complex of kidney
Vasodilation of afferent arterioles
Increase GFR
TUBULOGLOMERULAR MECHANISM OF AUTOREGULATION
Extrinsic
indirectly regulates GFR by maintaining systemic BP
Granular cells of juxtaglomerular complex of kidney
(Macula densa cells)
Renin
Angiotensin 2
Increase aldosterone adrenal cortex
Increase Na+ reabsorption kidney tubules: water follows
Increase blood volume
Increase systemic blood pressure
HORMONAL
Vasoconstriction of systemic arterioles
Increase peripheral resistance
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Inhibits baroreceptors in blood vessels of systemic circulation
Sympathetic nervous system
NEURAL
DECREASE SYSTEMIC BLOOD PRESSURE