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MALE REPRO (Epididymis (Structure: (Caput (Fluid resorption, Histology -…
MALE REPRO
Epididymis
Sperm must mature here to become motile
Passage 6-12 days
Structure:
Caput
Fluid resorption
Histology - stereocilia
Corpus
Histology - Cells lower in height
MATURATION
Structure
Condensation of CHROMATIN
Membrane mods
Addition of glycoproteins
Decapacitation factors
Metabolism
Depression of activity
Reliance on external fructose
Motility
cAMP of tail increases
Cauda
Histology - bands of smooth muscle
Storage + ejaculation
Testis
Seminiferous tubules
Sertoli cells
Nourish via gap junctions
Transport proteins
Manage waste
Testosterone > dihydrotestosterone
Stimulates:
Spermatogenesis
Reproductive tract
Stimulated by FSH
Developing spermatogonia
Between tubules
Leydig cells
Produce androgens
Cholesterol > Progesterone > Testosterone
Into blood
Feedback to Anterior pituitory and hypothalamus
Into semineferous tubules
Stimulated by LH
Spermatogenesis
Phases:
Mitotic proliferation
Produce spermatogonia
Occurs in basal compartment
Meiotic division
Generates genetic diversity
Diploid > Haploid
Spermatocytes > spermatids
Occurs in adluminal compartement
Cytodifferentiation
Packages genes
Spermatids > spermatazoa
Happens in waves
Infertility
Oestrogen pollution
Epigenetic effect
Hormones
Hypothalamus
Releases GnRH
Anterior pituitory
Releases LH + FSH
Testis
Releases testosterone
Negative feedback loop