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13-Neonatal sepsis (INTRODUCTION (COMPLICATION (DIC), Humoral, cellular…
13-Neonatal sepsis
INTRODUCTION
Humoral, cellular and neutrophil function decreased in neonates --> infection susceptibility
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EVALUATION
Thorough birth history; rupture of membranes?, meconium, gest age. osv
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Physical exam
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Abdominal distention, organomegaly?
erythema, petechia, vesicles
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ETIOLOGY
Early onset
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Entry: conjunctiva, resp tract, umbiolicus, skin and oropharynx
Organisms: B streptococci(GSB), e.coli, G- enterococci, List.Monocytogenes.
late onset
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Pseudomonas a, candida, anaerobes and MRSA
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MANAGEMENT
Infant screening
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Blood, urine and CSF culture+ATB coverage
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enterococci
aminopencillins: amoxillin, ampicillin
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