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Depression and Evolution (Serotonin Receptor # (Heisler et al, 1998…
Depression and Evolution
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Hartig, Branchek Weinshank, 1997
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found homologues (equivalent receptor) in rat for human serotonin receptors. compare homologues, found 99% similar
Carter et al, 2005
took healthy adults, gave 4 conditions: placebo, 5HT antagonist, 5HT agonist, and antagonist+agonist. Gave individuals WM/att'n tasks
agnoist causes decrease in attention, but not working memory. attentional control is high when high 5HT transmission to left VLPFC
Winstanley et al., 2003
put tubes in rats brains in mPFC, trained them to do att'n/WM/rxn time task.
put 5HT antagonist/agonist, saw what affects had on task ctrl. Agonist caused reduced attentional performance, increased Impulsive behaviour but increased accuracy.
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Rumination
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Sheeber et al., 2001
depressed individuals have elevated ability to solve social issues, probably because high levels of rumination
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