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Pathophysiology of OAB (http://www.sciencedirect.com/science/article/pii/S…
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measures
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measuring uroflow and pressure flow to determine
bladder outlet obstruction, urethral closure pressure for the
diagnosis of genuine stress incontinence, ambulatory urodynamics,
and cystometry. A cystometrogram measures
how much one’s bladder can hold, how much pressure
builds up inside the bladder as it stores urine, and how full
it is when one feels the urge to urinate.
causes
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catagories
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myogenic
(e.g., obstruction, benign prostatic hyperplasia),
inflammatory (e.g., interstitial cystitis),
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changes
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neurological changes
afferent neurons in dorsal root ganglia enlarge resulting in a delay and micturition pathway is reorganized from a spinobulbospinal loop to a predominantly spinal network
ischemia if present impairs contractibility and gives rise to detrusor hyperactivity with impaired contractility or unstable contractions in the absence of sensation of urgency
molecular trigger: nerve growth factor. This might affect that membrane conductance,and thus excitability of DRG neurons