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OAB (17922784) (symptoms (frequency, nocturia, urgency, urge incontinence,…
OAB (17922784)
symptoms
frequency
nocturia
urgency
urge incontinence
may be associated with DO
assessment of drugs
bladder diary stating voiding patterns
micturition frequency
no of urgency and incontinence episodes
volume voided per micturition
urodynamic studies with Pressure vs flow rate data
bladder volume at first involuntary contraction
involuntary detrusor
contraction amplitude
postvoid residual urine volume
maximum cystometric
capacity
max flow rate
causes
DO(involuntary contraction of detrusor during filling) causes
BOO - cholinergic denervation of detrusor leading to enhanced muscarine sensitivity to ACh
peripheral (urothelial, myogenic, autonomous)
central signaling
release of ACh from urothelium and other sources even in storage phase
enhanced myogenic contractions by muscarine stimulation
altered structure
bladder denervation
infiltration by elastin and collagen
changes in protrusion junction leading to enhanced coupling
change in excitability of C fibres leading to afferent signalling even due to chemicals
muscarine receptors on suburothelium found to be correlated with DO
in hypertrophied bladder M2 receptor density and significance increases