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Transdermal microemulsions of Boswellia carterii Bird (Study (ตัวแปร…

- - - - steroidal (lipophilic)
      - acetyl-11-keto-beta-boswellic acid (AKBA)
        
        The strongest inhibitory efficacy
        
        11-keto-beta-boswellic acid (KBA)
      - Selectively inhibit leukotriene synthesis 5-LO
      - do not solubilize in the intestional fluid
      - limited systemic bioavailability
      - side effects
        
        abdominal discomfort
        
        nausea
        
        epigastric pain
        
        hypergasidity
        
        diarrhea
  - - - enhance penetration of substances into and through biologic membrane
      - easy to formulate
      - low viscocity
      - self-preservative property
- - - - Used Soxhlet apparatus
      - chromatographic technique to investigate phytochemical
    - - The AKBA content was estimated as 6.45%± 0.46
      - detected and identified using NMR, ESI/MS, LC/MS
      - HPLC
    - - Pseudo-ternary phase diagrams
        
        Oil : Capmul MCM C8
        
        Surfactant: Tween80 and Labrasol
        
        Tween80 reached higher ME zone
        
        Tween 80 has minimal toxicity
        
        Co-surfactant: PEG400
        
        Water
        
        Selected based on solubility study
        
        enlarged region MEs
        
        Ratio of oil decrease
        
        Smix increase
    - - Determine drug content
        
        ME4
        
        Drug encap 100%
        
        Smix Ratio 2:1
        
        Oil 17.5%
        
        ME1
        
        Drug encap 83%
        
        Oil 7.78%
        
        Smix Ratio 1:1
    - - pH measurement
      - Electrical conduction
      - TEM
      - Globule size&PDI
    - - Abdominal skin of female Wistar rats
      - using HPLC
      - AKBA permeated
        
        ME1 97%
        
        ME4 30%
    - - Erythema scores of both MEs are close to the control
      - Experiments
        
        Gr2 0.8% formalin (standard irritant)
        
        Gr3 ME1 test group
        
        Gr1 no application (control)
        
        Gr4 ME4 test group
    - - Tests
        
        Gr2 0.5% piroxicam
        (standard transdermal anti-inflammatory)
        
        Gr3 ME1 test group
        
        Gr1 no application (control)
        
        Gr4 ME4 test group
      - ME1 exhibits significantly higher anti-inflammatory effect
        compared to both
- - - - ME formulations
        
        ME1
        
        ME4
    - - Skin irritancy
      - ex vivo permeation
      - Characterizations
      - in vivo anti-inflammatory
    - - Methods
      - Materials