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CAUSES OF THROMBOCYTOPENIA (DECREASED PLATELET PRODUCTION (Amegakaryocytic…
CAUSES OF THROMBOCYTOPENIA
DECREASED PLATELET PRODUCTION
Amegakaryocytic thrombocytopenia
Aplastic anemia
Myelodysplastic syndrome (MDS)
Bone marrow hypoplasia
Bone marrow infiltration
Ineffective thrombopoiesis
ABNORMAL DISTRIBUTION
Hypersplenism
Dilutional, from massive transfusion
ARTIFACTUAL (PSEUDOTHROMBOCYTOPENIA)
EDTA-induced Platelet Agglutination (EIPA)
Platelet Satellitism
Cold Agglutinins
Giant platelets or Megathrombocyte
INCREASED DESTRUCTION
Nonimmune mechanisms
von Willebrand disease
DIC
Severe bleeding
Immune mediated
Drugs including heparin induced
Post-transfusion purpura
Systemic lupus erythematosus