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Benign diseases of Vulva (Bartholin Cyst (Obstruction of duct, secretion…

- - - - enlarge nuclei
      - perinuclear halos
- - - - young age sex
      - multiple sex partners
      - male gays w/ gays
    - - flesh-colored
      - Discrete, white (hyperkeratotic)
      - slightly raised lesions
    - - pleomorphism, hyperchromasia
      - skin appendages >50%
      - Nuclear enhancement, abnormal mitotic figures
      - Grading
        
        VIN 3: severe dysplasia>2/3 epith carcinoma in situ full thickness,
        
        VIN 2 Moderate dysplasia 1/2-2/3 epith
        
        VIN 1: Mild dysplasia lower 3rd epith
  - - - Basaloid & warty carcinoma
        
        high oncogenic risk HPV
      - Keratinizing SCC
        
        not related to HPV infection
    - - depth of invasion
      - lymphatic vessel involvement
      - size of tumor
      - <2cm lesion->60-8-% 5yr survival rate