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22-immunodeficiency (T-cell defects (Severe combined immunodeficiency(SCID…
22-immunodeficiency
T-cell defects
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Wiskott aldrich, X-linked
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Duncan sy, X-linked
inability to respond to Epsein Barr virus, either succumb to the initial infection or develop secondary lymphoma.
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Complement defects
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Gives recurrent bacterial infections. SLE like illness. Recurrent meningococcal infections. C5b to C9 failure.
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DIAGNOSIS:
levels of C4, c3, ch50 acivity.
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Management
ATB prophylaxis
Tcell
Cotrimoxazole, fluconazole
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B -cell defects
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Selective IgA def. Most common primary immune defect Recurrent ear,sinus and pulm infections.
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