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Key Product Attribute (Delivery Site (Local (Peripheral Airways (Profile…
Key Product Attribute
Delivery Site
Systemic
Peripheral Airways (1-2 microns)
High Aqueous Solubility/Dissolution
Amorphous
Local
Peripheral Airways
Profile and Form Variable
Central Airways
Dose
High (>50%)
Low Excipient Load
DSPC/DPPC/Salt
Low (<50%)
High Excipient Load
Tre/Leu/NaCit/bulking
Stability
Chemical
Add appropriate ph buffer salts
Phsycial
Control form and add stablizing excipients as API requires
Aqueous Solubility
High
Easy path forward as single solvent
Low