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Aetiology of Cancer (Inherited conditions
A germline deletion of 1 allele…
Aetiology of Cancer
Inherited conditions
A germline deletion of 1 allele and subsequent mutation of the remaining allele leads to carcinogenesis
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Physical
Radiation - increases DNA damage leading to the accumulation of mutations in tumour suppressor and oncogenes
Radiation source:
- High energy (photons or electrons)
- Low energy (x-rays or y-rays from cobalt source)
- UV light - skin cancers
Level of exposure:
- Accumulation of a radioactive isotope in a particular tissue
- e.g. thyroid cancer and radioactive iodine
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