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Bladder (Filling (parasympathetic (adapts to increased volume by…

- - - - increased expression of mechanoreceptor ENaC
        
        enhances substrate release upon bladder stretching
  - - - activation of C fibres
    - - more relevant when BOO also present
        
        bladder hypertropthy
        
        partial denervation
        
        supersensitivity of cholinergic muscarine receptors
        
        increased expression and purinergic mediated response
        
        increased cell to cell communication due to upregulation of gap junction
        
        increased intervescicle pressure
      - interstitial cells mediated enhanced autonomous activity of detrusor
- - - - passive
        
        simultaneous transfer of intraabdominal pressure to urethra and bladder
      - active
        
        urethra P increases before coughing
        
        urethra pressure increase greater than bladder pressure increase
        
        urethra closure pressure reduced
- - - - initiates micturition
    - - maintains the urination drive
    - - A delta fibres
        
        more important
      - C fibres
        
        higher threshold