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Gene Expression (DNA Methylation (Methylation of Cytosine (CpG islands,…
Gene Expression
DNA Methylation
Methylation of Cytosine
CpG islands
Blockage in transcription
Cis Elements
High methylation of X for X inactivation
Found in cancer
Methylation patterns are unique
Hypermethylation causes blockage
Tumor suppressors are blocked
RNA Interference
miRNA binds
complementary to mRNA
degredation
used only for gene regulation
no translation/ribosome binding
Histone Modification
Shortens overall DNA length
DNA wraps around histones
Compartmentalizes genes
Heterochromatin
Dense DNA methylation
Compact
Transcriptionally active
Euchromatin
Low DNA methylation
Condensed
Transcriptionally active
genome
replication
DNA
RNA