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IMMUNE SYSTEM (BONE MARROW (PROGENITOR B CELL (PRE B CELL (IMMATURE B…

- - - - IMMATURE B CELL
        
        MATURE B CELL
        
        PLASMA CELL
        
        MEMORY B CELL
  - - - PRE T CELL
- - - - B cell
        
        plasma cell
        
        memory B cell
      - T cell
        
        Th cell
        
        TH1
        
        activates macrophages to kill intravesicular pathogens
        
        TH2
        
        activate B cell to make antibody
        
        Tc cell
        
        kills infected cell
        
        release
        
        perforin
        
        polymerizes to form a pore in target membrane
        
        granzymes
        
        serine proteases,which activates apoptosis once in the cytoplasm of the target cell
        
        granulysin
        
        induce apoptosis
        
        memory T cells
        
        long-lived
        
        can be activated for secondary and rapid response same to Ag
        
        accessory molecules
        
        CD4
        
        CD8
        
        CD3 complex
        
        required for signl transduction from TCR molecule to intracellular tyrosine kinase
      - Natural killer cell
    - - Neutrophil
      - eosinophil
      - Basophil
      - mast cell
      - monocytes
        
        dendritic cell
        
        macrophage
- - - - produce antibody (IgG, IgA, IgM,IgD, IgE)
      - activated by Th2 cell
  - - - MHC class1
        
        present peptide derived from proteins in cytosol
        
        protein chains
        
        alpha chain
        
        alpha 1 and 2
        
        binding site for peptide from antigen
        
        alpha 3
        
        CD8 bind site
        
        B2 microglobulin chain
      - MHC class 2
        
        present peptides derived originating in intracellular vesicles
        
        protein chain
        
        alpha chain
        
        B chain
        
        B2
        
        CD4 binding site
        
        alpha 1 and B2
        
        binding site for peptide from antigen