Please enable JavaScript.

Coggle requires JavaScript to display documents.

(Clinical Presentation (Chronic form of ICD: The symptoms may be observed…

- - - - Cleaners
      - Culinary workers
    - - pastry cooks- 16.9 cases per 10,000 worker/year
      - bakers-23.5 cases per 10,000 worker/year
      - hairdressers- 46.9 cases per 10,000 worker/year
- - - - excessive water loss
      - increase penetration of irritants and allergen
      - altered epidermal calcium
      - slow/deficient lipid production
      - increase PH of the skin
  - - - release of pro-inflammatory cytokines
        
        Tumor necrosis alpha
        
        release of CCL20
        
        CXCL8
        
        chemokines signals
        
        attract mononuclear and poly nuclear cells
        
        IL-1a :
        
        IL-1B
        
        IL-6
      - fibroblast release
        
        active mediators
        
        CXL8
        
        CXL1
        
        CCL2
- - - - keratinocytes synthesis lipids
        
        accumulate lamellar granules
        
        transported to intracellular space
        
        enzymatic process occurs
        
        bilayer of ceramides, cholesterol, fatty acids are formed
        
        Desquamation of skin